|Kyle MacLachlan||Jeffrey Beaumont|
|Isabella Rossellini||Dorothy Valens|
|Dennis Hopper||Frank Booth|
|Laura Dern||Sandy Williams|
|Hope Lange||Mrs. Williams|
|Priscilla Pointer||Mrs. Beaumont|
|Frances Bay||Aunt Barbara|
College student Jeffrey Beaumont returns home after his father has a stroke. When he discovers a severed ear in an abandoned field, Beaumont teams up with detective's daughter Sandy Williams to solve the mystery. They believe beautiful lounge singer Dorothy Vallens may be connected with the case, and Beaumont finds himself becoming drawn into her dark, twisted world, where he encounters sexually depraved psychopath Frank Booth .