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| Greer Garson | Edna Gladney |
| Walter Pidgeon | Sam Gladney |
| Felix Bressart | Dr. Max Breslar |
| Marsha Hunt | Charlotte |
| Fay Holden | Mrs. Kahly |
| Samuel S. Hinds | Mr. Kahly |
| Kathleen Howard | Mrs. Keats |
| George Lessey | Mr. Keats |
| William Henry | Allan Keats |
| Henry O'Neill | Judge |
| John Eldredge | Damon |
| Clinton Rosemund | Zeke |
| Theresa Harris | Cleo |
| Charles Arnt | G. Harrington Hedger |
| Cecil Cunningham | Mrs. Gilworth |
| Ann Morriss | Mrs. Loring |
| Marc Lawrence | La Verne |
| Frank Darien | Jones |
| Will Wright | Texas Senator (uncredited) |
| Edwin Maxwell | City Councilman (uncredited) |
| Almira Sessions | Mrs. Brown |
Edna Gladney lost her son when he was very young. By chance she discovered the injustice within the law towards children whose parents are unknown, and decided to open an orphanage for these children, despite the stigma. She fought against the unfair laws that discriminated against children born out of wedlock.
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