| Julianne Moore | Doctor's Wife |
| Mark Ruffalo | Doctor |
| Alice Braga | Woman With Dark Glasses |
| Yusuke Iseya | First Blind Man |
| Yoshino Kimura | First Blind Man's Wife |
| Don McKellar | Thief |
| Maury Chaykin | Accountant |
| Mitchell Nye | Boy |
| Danny Glover | Man With Black Eye Patch |
| Gael García Bernal | Bartender/King of Ward Three |
| Sandra Oh | Minister of Health |
When an epidemic of a disease known as the ``white sickness'' appears in her city, the wife of a doctor is one of the few individuals left who still has sight. Sent to a government asylum along with her now-blind husband, she sees conditions deteriorate until civilization itself is in jeopardy, prompting her break-out of the asylum to lead a small group to freedom.
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