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| Tim Allen | Eliot Arnold |
| Rene Russo | Anna Herk |
| Stanley Tucci | Arthur Herk |
| Tom Sizemore | Snake |
| Johnny Knoxville | Eddie |
| Dennis Farina | Henry |
| Jack Kehler | Leonard |
| Janeane Garofalo | Monica Romero |
| Patrick Warburton | Walter Kramitz |
| Ben Foster | Matt Arnold |
| Zooey Deschanel | Jenny Herk |
| Omar Epps | Seitz |
| Jason Lee | Puggy |
| Sofía Vergara | Nina |
| Andy Richter | Jack/Ralph Pendick |
Based on Pulitzer Prize-winning humorist Dave Barry's best-selling first novel, ``Big Trouble'' tells the story of how a mysterious suitcase brings together, and changes, the lives of a divorced dad, an unhappy housewife, two hitmen, a pair of street thugs, two love struck teens, two FBI men and a psychedelic toad.
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