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| Martin Lawrence | Malcolm Turner |
| Nia Long | Sherry Pierce |
| Emily Procter | Leah Fuller |
| Zachary Levi | Kevin |
| Mark Moses | Tom Fuller |
| Kat Dennings | Molly |
| Chloe Grace Moretz | Carrie |
| Marisol Nichols | Liliana Morales |
| Sarah Brown | Constance Stone |
| Michelle Parylak | JoAnne |
| Elton LeBlanc | Asst. Bingo Caller |
After his mentor is killed, an FBI agent reprises his disguise as a fat old lady and takes a job as a nanny in a crime suspect's house. While working on the case, the agent diffuses a threat to homeland security and brings a fractured family closer together.
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