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| John Wayne | Jacob McCandles |
| Richard Boone | John Fain |
| Maureen O'Hara | Martha McCandles |
| Patrick Wayne | James McCandles |
| Chris Mitchum | Michael McCandles |
| Bobby Vinton | Jeff McCandles |
| Bruce Cabot | Sam Sharpnose |
| Glenn Corbett | O'Brien |
| Harry Carey Jr. | Pop Dawson |
| John Doucette | Buck Duggan |
| Jim Davis | Head of lynching party |
| John Agar | Bert Ryan |
| Gregg Palmer | John Goodfellow |
| Robert Warner | Will Fain |
| Jim Burk | Trooper |
| Dean Smith | James William ''Kid'' Duffy |
| Ethan Wayne | Jacob McCandles |
| Virginia Capers | Delilah |
| William Walker | Moses Brown |
| Jerry Gatlin | Stubby |
| Tom Hennesy | Mr. Sweet |
| Don Epperson | Saloon bully in Escondero |
| Everett Creach | Walt Devries |
| Jeff Wingfield | Billy Devries |
| Hank Worden | Hank |
The avenging head of the McCandle clan returns to his estranged family and leads the search for his kidnapped grandson. Big Jake sets off, his sons in tow, to deliver the ransom to the kidnappers, but has little intention of handing it over without a fight.
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