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| Charles Grodin | George Newton |
| Bonnie Hunt | Alice Newton |
| Dean Jones | Herman Varnick, D.V.M. |
| Nicholle Tom | Ryce Newton |
| Christopher Castile | Ted Newton |
| Sarah Rose Karr | Emily Newton |
| Oliver Platt | Harvey |
| Stanley Tucci | Vernon |
| David Duchovny | Brad |
| Patricia Heaton | Brie |
Children talk their father into letting them keep a St. Bernard puppy, which grows to be a problem.
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