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| Boris Karloff | |
| Anna Lee | |
| Billy House | |
| Glenn Vernon | |
| Jason Robards | |
| John Newton | |
| Richard Fraser | |
| Ian Wolfe | |
| Leland Hodgson | |
| Elizabeth Russell |
After getting a glimpse of the conditions at the St. Mary's of Bethlehem Asylum, known as ''Bedlam,'' Nell Bowen is concerned that the patients are being mistreated. When she seeks to better the situation, the head of St. Mary's, George Sims, uses his political savvy to have Nell committed. Being within St. Mary's does not deter Nell, however, and she starts to turn the patients against Sims in a bid to violently oust him from power.
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