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| Courtney Love | Joan Vollmer Burroughs |
| Norman Reedus | Lucien Carr |
| Ron Livingston | Allen Ginsberg |
| Kiefer Sutherland | William S. Burroughs |
| Daniel Martinez | Jack Kerouac |
| Kyle Secor | Dave Kammerer |
| Sam Trammell | Lee |
| Lisa Sheridan | Sadie |
| Rene Rubio | Bill Jr. |
| Georgiana Sirbu | Julie |
| Tommy Perna | Dwight |
| Alec Von Bargen | Heard |
In New York City, just as the Beat literary movement is beginning to take form, writer William S. Burroughs courts the woman who would become his second wife, fellow author Joan Vollmer . As Burroughs' and Vollmer's affiliation with poets Jack Kerouac and Allen Ginsberg draws them into a world of sex, violence and unbridled creativity, the dark center of their tumultuous union threatens to come to a head.
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