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| Kurt Russell | Stephen 'Bull' McCaffrey/Dennis McCaffrey |
| William Baldwin | Brian McCaffrey |
| Robert De Niro | Donald 'Shadow' Rimgale |
| Donald Sutherland | Ronald Bartel |
| Jennifer Jason Leigh | Jennifer Vaitkus |
| Scott Glenn | John 'Axe' Adcox |
| Rebecca De Mornay | Helen McCaffrey |
| Jason Gedrick | Tim Krizminski |
| J.T. Walsh | Alderman Marty Swayzak |
| Tony Mockus Sr. | Chief John Fitzgerald |
| Cedric Young | Grindle |
| Jack McGee | Schmidt |
| Mark Wheeler | Pengelly |
| Clint Howard | Ricco, Pathologist |
| Ryan Todd | Brian, Age 7 |
| John Duda | Stephen, Age 12 |
Chicago firefighting brothers Stephen and Brian have been rivals since childhood. Brian, struggling to prove himself, transfers to the arson unit. There he aids Don in his investigation into a spate of fires involving oxygen-induced infernos called backdrafts. But when a conspiracy implicating a crooked politician and an arsonist leads Brian back to Stephen, he is forced to overcome his brotherly competitiveness in order to crack the case.
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