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| Brad Pitt | Richard |
| Cate Blanchett | Susan |
| Gael García Bernal | Santiago |
| Kôji Yakusho | Yasujiro |
| Adriana Barraza | Amelia |
| Rinko Kikuchi | Chieko |
| Said Tarchani | Ahmed |
| Boubker Ait El Caid | Yussef |
| Elle Fanning | Debbie |
| Nathan Gamble | Mike |
| Mohamed Akhzam | Anwar |
| Peter Wight | Tom |
| Abdelkader Bara | Hassan |
| Mustapha Rachidi | Abdulla |
| Driss Roukhe | Alarid |
| Clifton Collins Jr. | Officer at Border Crossing |
| Robert Esquivel | Luis |
| Michael Peña | John |
| Yuko Murata | Mitsu |
| Satoshi Nikaido | Kenji |
An accident connects four groups of people on three different continents: two young Moroccan goatherds, a vacationing American couple, a deaf Japanese teen and her father, and a Mexican nanny who takes her young charges across a border without parental permission.
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