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| Sharon Gless | |
| Michael S. Berliner | Himself (editor of Rand's letters) |
| Harry Binswanger | Himself (professor, friend) |
| Sylvia Bokor | Herself (artist) |
| Daniel Greene | Himself (artist) |
| Cynthia Peikoff | Herself (friend, secretary) |
| Leonard Peikoff | Himself (intellectual heir, friend) |
| Al Ramrus | Himself (writer, producer) |
| John Ridpath | Himself (professor, York University) |
| Mike Wallace | Himself (CBS News correspondent) |
| Janne Peters | Kay Gonda |
| Peter Sands | Dietrich von Esterhazy |
| Buzz Aldrin | Himself (on the Moon) |
Director Michael Paxton uses interviews and the controversial author's own writings to explore her life.
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