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| Robert De Niro | Leonard Lowe |
| Robin Williams | Dr. Malcolm Sayer |
| Julie Kavner | Eleanor Costello |
| Ruth Nelson | Mrs. Lowe |
| John Heard | Dr. Kaufman |
| Penelope Ann Miller | Paula |
| Alice Drummond | Lucy |
| Judith Malina | Rose |
The story of a doctor's extraordinary work in the Sixties with a group of catatonic patients he finds languishing in a Bronx hospital. Speculating that their rigidity may be akin to an extreme form of Parkinsonism, he seeks permission from his skeptical superiors to treat them with L-dopa, a drug that was used to treat Parkinson's disease at the time.
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