| Jack Nicholson | Melvin Udall |
| Helen Hunt | Carol Connelly |
| Greg Kinnear | Simon Bishop |
| Cuba Gooding Jr. | Frank Sachs |
| Skeet Ulrich | Vincent Lopiano |
| Shirley Knight | Beverly Connelly |
| Yeardley Smith | Jackie Simpson |
| Lupe Ontiveros | Nora Manning |
Melvin Udall is an obsessive-compulsive writer of romantic fiction who's rude to everyone he meets, including his gay neighbor Simon, but when he has to look after Simon's dog, he begins to soften and, if still not completely over his problems, finds he can conduct a relationship with the only waitress at the local diner who'll serve him.
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