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| Max Minghella | Jerome |
| John Malkovich | Professor Sandford |
| Sophia Myles | Audrey |
| Jim Broadbent | Jimmy |
| Anjelica Huston | Sophie |
| Ethan Suplee | Vince |
| Matt Keeslar | Jonah |
| Steve Buscemi | Broadway Bob |
| Joel David Moore | Bardo |
| Chris McKenna | Mikey |
| Marc Vann | Kevin |
| Charles Schneider | Prof. Pidgeon |
| Charlie Talbert | Jason |
| Jeff LeBeau | David Timlin |
| Jesse Flanagan | Hurst |
Jerome, a freshman at a prestigious art school, dreams of making it big, but his arrogance and affectations hamper his chances. Jealous of a clueless jock, he hatches a plan to make a splash in the art world and win the heart of the prettiest gal in school.
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