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| Jason Biggs | Jim |
| Alyson Hannigan | Michelle |
| Chris Klein | Oz |
| Thomas Ian Nicholas | Kevin |
| Tara Reid | Vicky |
| Seann William Scott | Stifler |
| Mena Suvari | Heather |
| Eddie Kaye Thomas | Paul |
| Jennifer Coolidge | Stifler's Mom |
| Eugene Levy | Jim's Dad |
| Natasha Lyonne | Jessica |
| Shannon Elizabeth | Nadia |
| Dania Ramirez | Selena |
| Katrina Bowden | Mia |
| Jay Harrington | Dr. Ron |
| Ali Cobrin | Kara |
| Chuck Hittinger | AJ |
| Chris Owen | Sherman |
| Neil Patrick Harris | Celebrity Dance-Off Host |
In the summer of 1999, four small-town Michigan boys began a quest to lose their virginity. In the ensuing years, Jim and Michelle have married, though Kevin and Vicky said goodbye. Oz and Heather grew apart, but Finch still has the hots for Stiffler's mom . These lifelong friends come home to reminisce about -- and become inspired by -- their former teen selves.
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