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| Ioan Gruffudd | William Wilberforce |
| Romola Garai | Barbara Spooner |
| Benedict Cumberbatch | William Pitt |
| Albert Finney | John Newton |
| Michael Gambon | Lord Charles Fox |
| Rufus Sewell | Thomas Clarkson |
| Youssou N'Dour | Olaudah Equiano |
| Ciarán Hinds | Lord Tarleton |
| Toby Jones | Duke of Clarence |
| Nicholas Farrell | Henry Thornton |
| Sylvestra Le Touzel | Marianne Thornton |
| Jeremy Swift | Richard the Butler |
| Stephen Campbell Moore | James Stephen |
| Bill Paterson | Lord Dundas |
| Nicholas Day | Sir William Dolben |
| Georgie Glen | Hannah Moore |
In 18th-century England, House of Commons member William Wilberforce and his close friend and a future prime minister, William Pitt, begin a lengthy battle to abolish Great Britain's slave trade. Though Wilberforce's legislation is soundly defeated in 1791, his growing affection for Barbara Spooner inspires him to take up the fight once more.
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