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| Chris Farley | Bartholomew Hunt |
| Matthew Perry | Leslie Edwards |
| Eugene Levy | Guy Fontenot |
| Kevin Dunn | Hidalgo |
| Lisa Barbuscia | Shaquinna |
| Bokeem Woodbine | Jonah |
| Steven M. Porter | Higgins |
| David Packer | Bidwell |
| Hamilton Camp | Pratt |
| Lewis Arquette | Merchant |
| Patrick Crenshaw | Jackson |
| Christian Clemenson | Father Girard |
Two explorers are racing Lewis and Clark to the Pacific Ocean in 1804. Edwards is a glory-seeking fop who's out of his league, Hunt is a slovenly, clumsy tracker with a soft spot for toilet humor. Along with a team of misfits and losers, the duo wreaks havoc on the American frontier.
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