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| Johnny Depp | The Mad Hatter |
| Mia Wasikowska | Alice |
| Anne Hathaway | The White Queen |
| Helena Bonham Carter | The Red Queen |
| Matt Lucas | Tweedledum/Tweedledee |
| Crispin Glover | |
| Marton Csokas | |
| Tim Pigott-Smith | |
| Lindsay Duncan | |
| Geraldine James | |
| Leo Bill | |
| Jemma Powell | |
| Mairi Ella Challen | |
| Stephen Fry | |
| Alan Rickman | |
| Michael Sheen | |
| Timothy Spall | |
| Christopher Lee | |
| Paul Whitehouse | |
| Barbara Windsor |
Alice, now 19-years-old, returns to Wonderland, where she must find her true destiny and put an end to the Red Queen's reign of terror.
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