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| Will Smith | Cassius Clay/Muhammad Ali |
| Jamie Foxx | Drew "Bundini" Brown |
| Jon Voight | Howard Cosell |
| Mario Van Peebles | Malcolm X |
| Ron Silver | Angelo Dundee |
| Jeffrey Wright | Howard Bingham |
| Mykelti Williamson | Don King |
| Jada Pinkett Smith | Sonji |
| Michael Michele | Veronica |
| Joe Morton | Chauncy Eskridge |
| Paul Rodriguez | Dr. Ferdie Pacheco |
| Bruce McGill | Bradley |
| Barry Shabaka Henley | Herbert Muhammad |
| Giancarlo Esposito | Cassius Clay, Sr. |
| Laurence Mason | Luis Sarria |
| LeVar Burton | Martin Luther King, Jr. |
| Albert Hall | Elijah Muhammad |
| David Cubitt | Robert Lipsyte |
| Ted Levine | Joe Smiley |
| David Elliott | Sam Cooke |
| Shari Watson | Woman Singer |
| Malick Bowens | Joseph Mobutu |
| Michael Bentt | Sonny Liston |
| Alfred Cole | Ernie Terrell |
| Charles Shufford | George Foreman |
Muhammad Ali battles Sonny Liston, Joe Frazier and George Foreman and raises controversy outside the ring.
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