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| Jude Law | Alfie |
| Marisa Tomei | Julie |
| Omar Epps | Marlon |
| Nia Long | Lonette |
| Jane Krakowski | Dorie |
| Sienna Miller | Nikki |
| Susan Sarandon | Liz |
| Renee Taylor | Lu Schnitman |
| Dick Latessa | Joe |
| Jefferson Mays | Dr. Miranda Kulp |
| Gedde Watanabe | Wing |
| Kevin Rahm | Terry |
| Finlay Robertson | Bright Young Thing |
British-born ladies' man Alfie exploits his job as a New York City limousine driver to meet and sleep with attractive women -- which infuriates his pseudo-girlfriend Julie, a single mom. His libertine lifestyle is interrupted, however, when his girl-crazy ways end up hurting his best friend, Marlon . Desperate, Alfie attempts a go at monogamy with the ravishing Nikki, but even her good looks aren't enough to keep him out of trouble for long.
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