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| Tyler Perry | Dr. Alex Cross |
| Matthew Fox | Picasso |
| Edward Burns | Thomas Kane |
| Rachel Nichols | Monica Ashe |
| Jean Reno | Leon Mercier |
| Cicely Tyson | Nana Mama |
| Carmen Ejogo | Maria Cross |
| Giancarlo Esposito | Daramus Holiday |
| John C. McGinley | Capt. Richard Brookwell |
| Stephanie Jacobsen | Fan Yau Lee |
| Werner Daehn | Erich Nunemacher |
| Yara Shahidi | Janelle Cross |
| Sayeed Shahidi | Damon Cross |
| Bonnie Bentley | Detective Jody Klebanoff |
| Chad Lindberg | Chemist |
| Simenona Martinez | Pop Pop Jones |
More Alex Cross Pictures
Alex Cross works as a detective/psychologist for the Detroit Police Department along with his lifelong friend, Tommy Kane, and detective Monica Ashe . Cross' latest case puts him on a collision course with Picasso, a cunning serial killer whose ultimate target is multinational industrialist Giles Mercier . Cross must find a way inside Picasso's head not only to catch the killer but also to stem the violent urges Cross feels.
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