| William Powell | Nick Charles |
| Myrna Loy | Nora Charles |
| James Stewart | David Graham |
| Elissa Landi | Selma Landis, Nora's Cousin |
| Joseph Calleia | Lichee Club Owner |
| Jessie Ralph | Aunt Katherine Forrest |
| Alan Marshal | Robert Landis |
| Penny Singleton | Polly Byrnes |
| William Law | Lum Kee |
| Sam Levene | Lieutenant Abrams |
| George Zucco | Dr. Adolph Kammer |
Recently returned home from vacation, private detective Nick Charles and his socialite wife, Nora, are back on the case when Nora's cousin, Selma, reports her husband Robert missing. As the duo search for the disreputable Robert, Selma's friend David Graham, who secretly pines for her, aids the investigation. When the three begin to unravel Robert's secret life, the missing persons case turns into one of murder.