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| Jason Robards | Murray |
| Barbara Harris | Sandra |
| Martin Balsam | Arnold |
| Barry Gordon | Nick Burns/Wilbur Malcome Burns/Theodore Burns/Raphael Sabatini/Dr. Morris Fishbein/Woodrow Burns/Chevrolet Burns/Big Sam Burns/Lefty Burns |
| Gene Saks | Leo |
| William Daniels | Albert |
Determined to avoid employment, Murray Burns, an eccentric former TV writer, lives with his 12-year-old nephew, Nick, in a messy New York City apartment. When Nick's unconventional home life is discovered, Murray comes under the scrutiny of social worker Sandra Markowitz, whom he quickly charms. Attempting to be responsible for both Nick and Sandra, Murray begrudgingly looks for a job -- but can he truly commit to a more conventional life?
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