| Clint Eastwood | Joe |
| Marianne Koch | Marisol |
| Josef Egger | Piripero |
| Wolfgang Lukschy | John Baxter |
| John Wells | Ramón Rojo |
| Carol Brown | Antonio Baxter |
| Pepe Calvo | Solvanito |
| Antonio Prieto | Don Miguel Benito Rojo |
| Gian Maria Volonte | Ramón Rojo |
| Sieghardt Rupp | Esteban Rojo |
| Benny Reeves | Rubio |
| Margherita Lozano | Consuelo Baxter |
| Daniel Martin | Julian |
| Richard Stuyvesant | Chico |
The Man With No Name enters the Mexican village of San Miguel in the midst of a power struggle among the three Rojo brothers and sheriff John Baxter . When a regiment of Mexican soldiers bearing gold intended to pay for new weapons is waylaid by the Rojo brothers, the stranger inserts himself into the middle of the long-simmering battle, selling false information to both sides for his own benefit.
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