|Helen Hayes||Catherine Barkley|
|Gary Cooper||Lt. Frederic Henry|
|Adolphe Menjou||Maj. Rinald|
|Mary Philips||Helen Ferguson|
|Blanche Frederici||Head Nurse|
Frederic Henry, an American driving ambulances for the Italian Army during World War I, falls for British Red Cross nurse Catherine Barkley, to the displeasure of jealous commanding officer Major Rinaldi, who transfers Catherine to a different hospital out of spite. But after Frederic is injured on the battlefield, he is evacuated to Catherine's new hospital in Milan, and the star-crossed lovers begin their romance anew.