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| Isobel Hawking | Herself - Stephen Hawking's Mother |
| Stephen Hawking | Himself |
| Janet Humphrey | Herself - Stephen Hawking's Aunt |
| Mary Hawking | Herself - Stephen Hawking's Sister |
| Basil King | Himself - Hawking Family Neighbor |
| Derek Powney | Himself - Hawking Classmate at Oxford |
| Norman Dix | Himself - Hawking Classmate at Oxford |
| Robert Berman | Himself - Hawking Tutor at Oxford |
| Roger Penrose | Himself - Professor at Cambridge |
| Dennis Sciama | Himself - Professor at Cambridge |
| John Wheeler | Himself - Astrophysicist |
| Brandon Carter | Himself - Astrophysicist |
| George O. Brown | Himself - Astrophysicist |
In part an adaptation of cosmologist Stephen Hawking's popular book about his theories of the universe, this documentary also shows Hawking's daily life as he deals with the ALS that renders him virtually immobile and unable to speak without the use of computer. Hawking's friends, family, former classmates and peers are interviewed about not only his theories but the man himself. Director Errol Morris uses creative graphics to visually illustrate Hawking's complex ideas.
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