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| Joseph Gordon-Levitt | Adam |
| Seth Rogen | Kyle |
| Anna Kendrick | Katherine |
| Bryce Dallas Howard | Rachael |
| Philip Baker Hall | Alan |
| Anjelica Huston | Diane |
More 50/50 Pictures
Adam Lerner has always tried to take good care of his health, so it comes as a cruel surprise when he learns that he has malignant tumors along his spine. His doctor gives him a 50/50 chance of survival, but Adam tries to remain upbeat, though his mother and his friend Kyle, react badly to the news. Adam starts seeing a therapist, but their relationship threatens to cross the boundary between doctor and patient.
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