|Van Heflin||Dan Evans|
|Glenn Ford||Ben Wade|
|Leora Dana||Mrs. Alice Evans|
|Henry Jones||Alex Potter, town drunk|
|Richard Jaeckel||Charlie Prince|
|Robert Emhardt||Mr. Butterfield, Stage Line Owner|
|Sheridan Comerate||Bob Moons|
Dan Evans, a drought-plagued Arizona rancher, volunteers to take captured stagecoach robber and murderer Ben Wade from Bisbee to Contention City, where the criminal will be put aboard the 3:10 train to Yuma for his trial. Accompanied only by the town drunk, Alex Potter, Dan battles Wade's henchman, the murder victim's revenge-minded brother, and the temptation of the large bribe Wade offers in exchange for his freedom.