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| Sean Penn | Paul Rivers |
| Benicio Del Toro | Jack Jordan |
| Naomi Watts | Cristina Peck |
| Charlotte Gainsbourg | Mary Rivers |
| Melissa Leo | Marianne Jordan |
| Clea DuVall | Claudia |
| Danny Huston | Michael |
| Paul Calderon | Brown |
| Carly Nahon | Cathy |
| Claire Pakis | Laura |
The lives of a terminally ill professor and an ex-convict intersect with a woman who lost her family in a car accident.
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