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| Roy Scheider | Dr. Heywood Floyd |
| John Lithgow | Dr. Walter Curnow |
| Helen Mirren | Tanya Kirbuk |
| Bob Balaban | Dr. R. Chandra |
| Keir Dullea | Dave Bowman |
| Madolyn Smith | Caroline Floyd |
| Dana Elcar | Dimitri Moisevitch |
| Taliesin Jaffe | Christopher Floyd |
| James McEachin | Victor Milson |
| Mary Jo Deschanel | Betty Fernandez, Bowman's Wife |
| Elya Baskin | Maxim Brajlovsky |
| Savely Kramarov | Dr. Vladimir Rudenko |
| Oleg Rudnik | Dr. Vasili Orlov |
| Natasha Schneider | Irina Yakunina |
| Vladimir Skomarovsky | Yuri Svetlanov |
The man behind the 2001 space odyssey joins a U.S./Soviet mission nine years later to find out what went wrong.
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