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| Cameron Diaz | Joy McNally |
| Ashton Kutcher | Jack Fuller Jr. |
| Rob Corddry | Hater |
| Lake Bell | Tipper |
| Treat Williams | Jack Fuller Sr. |
| Dennis Farina | Banger |
| Jason Sudeikis | Mason |
| Dennis Miller | Judge Whopper |
| Zach Galifianakis | Dave the Bear |
| Michelle Krusiec | Chong |
| Deirdre O'Connell | Mrs. Fuller |
| Krysten Ritter | Kelly |
| Queen Latifah | Dr. Twitchell |
| Andrew Daly | Curtis |
During a wild vacation in Las Vegas, career woman Joy McNally and playboy Jack Fuller come to the sober realization that they have married each other after a night of drunken abandon. Not only that, but there is huge jackpot at stake. When an implacable judge freezes the prize money and refuses to grant an annulment, Joy and Jack are forced to try to make their impromptu marriage work.
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