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| Kal Penn | Kumar |
| John Cho | Harold |
| Rob Corddry | Ron Fox |
| Jack Conley | Deputy Frye |
| Roger Bart | Dr. Beecher |
| Neil Patrick Harris | Himself |
| Danneel Harris | Vanessa |
| Eric Winter | Colton |
| Paula Garcés | Maria |
| Jon Reep | Raymus |
| Missi Pyle | Raylene |
| Mark Munoz | Cyrus |
| James Adomian | George W. Bush |
| Beverly D'Angelo | Sally |
| Echo Valley | Tits Hemingway |
| David Krumholtz | Goldstein |
| Eddie Kaye Thomas | Rosenberg |
After the high-flying stoners try to smuggle a bong aboard a flight to Amsterdam, the two find themselves in jail on charges of terrorism. After making an amazing escape, Harold and Kumar flee to Texas by way of Florida, where they hope to convince Harold's well-connected friend to help them out of their predicament. The problem is, Harold's pal is about to marry Kumar's ex-sweetie .
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