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| Tina Fey | Kate Holbrook |
| Amy Poehler | Angie Ostrowiski |
| Greg Kinnear | Rob |
| Dax Shepard | Carl |
| Romany Malco | Oscar |
| Sigourney Weaver | Chaffee Bicknell |
| Steve Martin | Barry |
| Maura Tierney | Caroline |
| Holland Taylor | Rose |
| James Rebhorn | Judge |
| Denis O'Hare | Dr. Manheim |
| Kevin Collins | Architect/Rick |
| Will Forte | Scott |
| Fred Armisen | Stroller Salesman |
| John Hodgman | Fertility Specialist |
| Siobhan Fallon Hogan | Birthing Teacher |
When single executive Kate Holbrook decides the time is right to finally have a baby, she hires a working-class woman from South Philadelphia to act as her surrogate mother. However, Kate's careful planning goes out the window when the woman shows up on her doorstep needing a place to live. A comic battle of wills breaks out between the pair as they prepare for the blessed event and try not to kill one another in the process.
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