| Rank | PRV. RANK | MOVIE (DISTRIBUTOR) | WEEKEND GROSS | % CHANGE | THEATER COUNT | TOTAL GROSS | WEEK # |
| 1 | new | The Twilight Saga: New Moon (Summit) | $142,839,137 | - | 4,024 | $142,839,137 | 1 |
| 2 | new | The Blind Side (Warner Bros.) | $34,119,372 | - | 3,110 | $34,119,372 | 1 |
| 3 | 1 | 2012 (Sony) | $26,410,206 | -59% | 3,408 | $108,131,263 | 2 |
| 4 | new | Planet 51 (Sony) | $12,286,129 | - | 3,035 | $12,286,129 | 1 |
| 5 | 2 | Disney's a Christmas Carol (Walt Disney) | $12,275,024 | -44% | 3,578 | $79,836,002 | 3 |
| 6 | 3 | Precious (Lionsgate) | $10,881,772 | 85% | 629 | $21,277,521 | 3 |
| 7 | 4 | The Men Who Stare At Goats (Overture) | $2,829,031 | -51% | 2,056 | $27,680,089 | 3 |
| 8 | 7 | Couples Retreat (Universal) | $1,943,075 | -52% | 1,712 | $104,992,030 | 7 |
| 9 | 6 | The Fourth Kind (Universal) | $1,747,085 | -61% | 1,648 | $23,359,890 | 3 |
| 10 | 5 | Michael Jackson's This Is It (Sony) | $1,617,417 | -67% | 1,640 | $70,258,545 | 4 |
| 11 | 9 | Law Abiding Citizen (Overture) | $1,606,053 | -57% | 1,327 | $70,018,193 | 6 |
| 12 | 11 | Pirate Radio (Focus) | $1,460,592 | -49% | 883 | $5,184,068 | 2 |